6.11.2022 dávali v televízii starý slovenský film Zemianska česť, na ktorý sme takmer zabudli. Nevieme, či ho v telke dávali v súvislosti s práve ubehnuvšími voľbami alebo hroziacimi predčasnými voľbami do parlamentu, ale či už tak alebo onak, načasovanie nemohlo byť lepšie. Ide totiž o satiru na predvolebnú frašku sfilmovanú podľa románu Jána Kalinčiaka Reštavrácia.
Napriek tomu, že román pochádza z roku 1860, je až neuveriteľné, ako nadčasovo je napísaný, pretože charaktery a charakteristiky postavičiek, ako aj ich správanie, možno napasovať na všetky politické figúrky, ktoré sme u nás doposiaľ mali a stále máme. No a rovnako aj na voličov, ktorí tieto politické figúrky volia.
Repríza televíznej klasiky nás priviedla k zamysleniu, kde sú korene takého správania a takých charakterov. Vzhľadom na dobu, kedy román vznikol, je zrejmé, že s tým určite nemá nič spoločné obdobie socializmu, na ktoré sa často zvaľuje všetko zlé, čo sa u nás dialo a deje. Takto sme sa správali už dávnom pred socializmom. Je to teda v nás, v národe, v našich génoch, že sme takým falošným, úplatným, bezzásadovým a bezcharakterným národom? Necháme sa kúpiť za klobásu či poldeci pálenky?
Odkaz románu do dnešnej doby
Dá sa teda pobaviť a zasmiať aj na takom starom filme? Určite áno, najmä keď si v jeho hrdinoch predstavíme naše súčasné politické postavičky. Realita dnešných dní však, bohužiaľ, nie je ani trochu zábavná, takže ide skôr o smiech cez slzy.
Ako sa to vo filme vlastne skončilo? Všetci sa pobratali, funkcie si podelili a obidve bandy vládli v podstate spolu. Nikoho ani vtedy nezaujímalo, ako je na tom krajina, ako sa vodí obyčajnému ľudu. Za všetko hovoria posledné slová filmu: „Nuž, ľa! Čo sa statočný zeman natrápi, kým vyjde na psí tridsiatok!“. A čo tak parafráza na súčasnú dobu: „Nuž, ľa! Čo sa statočná Slovač natrápi, kým vyjde na psí tridsiatok!“.
Nuž, od toho asi už nemáme ďaleko, keďže sa od Kalinčiakových čias vlastne nič nezmenilo. Ale môže sa, stačí iba odstaviť podarených politikov a hlavne volebný systém, ktorý im šafárenie umožňuje. Práve preto je tu tento portál, aby poukázal, kde je podstata tohto zla. Kým si neuvedomíme tieto fundamentálne okolnosti, nie je možné ani hľadať riešenia.
Román Reštavrácia a film Zemianska česť tak ostávajú nielen skvelou komédiou, ale aj mementom, že tváre sa síce menia, no politické taktiky ostávajú zhruba rovnaké. Voľby boli, sú a vždy budú iba fraškou pre verejnosť, zorganizovanou ziskuchtivými a mocibažnými indivíduami.
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Hereof, the equilibrium of neurotransmitters in the mind, specifically norepinephrine (NE), dopamine (DA), and serotonin (5-HT), is a significant factor of the overall weight reduction residential properties of most appetite suppressants [14, 25, 64]
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Nonetheless, PYY3– 36 exists in the saliva of rats and human beings, and its anorectic effect appears to be mediated with activation of the details Y2 receptor shared in the lingual epithelial cells. Hence, the scientific tests of sublingual PYY3– 36 are in the early stages, and the results of these studies will certainly identify its restorative capacity in the therapy of excessive weight. In a just recently published post making use of a variant of the DIO rat design, tesofensine (0.5– 3 mg/kg sc) dose-dependently decreased nighttime food consumption with an ED50 of 1.3 mg/kg (Axel et al., 2010). The selective catecholaminergic setting of activity of tesofensine separates it from the combined noradrenergic/serotonergic system of sibutramine or the 5-HT2C receptor-mediated system of lorcaserin and d-fenfluramine.
The details time of day to take tesofensine would rely on the instructions supplied by the prescribing doctor or medical care professional. They will certainly consider various elements such as the individual’s clinical condition, other drugs being taken, and any specific considerations for optimal application. Tesofensine is a peptide that has actually been examined for its prospective effects on weight reduction, cognitive feature, and various other medical conditions.Discover the Power of Wound Recovery Peptides! Explore our collection of sophisticated peptides for faster and extra effective wound recovery at Genemedics.
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Additionally, it’s been noted to increase metabolism, including prioritizing fat oxidation over carbohydrate oxidation, with a general boosted degree of lipolysis. Although the method it works for weight loss is not completely understood yet, it’s thought that by inhibiting all three of these vital neurotransmitters, the mixed restraint leads to significantly lowered hunger degrees. By affecting natural chemicals in the brain, it can result in greater energy expense, therefore helping individuals shed more calories while at rest.
MK-0493 is a potent careful MC4 receptor agonist with by mouth bioavailability (Krishna et al., 2009). In human volunteers, MK-0493 produced a substantial decrease in calorie consumption, yet the effect was a lot smaller sized than that of the referral comparator anti-obesity drug, sibutramine (Krishna et al., 2009). In placebo-controlled scientific tests in overweight and overweight topics, a repaired dose of MK-0493 produced a little decrease from standard body weight at 12 weeks, yet the result was not substantially various from sugar pill.
The initial point to do before trying to include Tesofensine right into your health and health routine is to have a straightforward discussion with your medical professional or other relied on medical or doctor.
Very lately, it was revealed that CNS loss of GIPR renders computer mice resistant to GIP-induced body weight loss, suggesting that GIP manages basal metabolism by means of CNS GIPR signalling185. Corroborating the significance of this searching for, it is notable that the premium weight-lowering effect of MAR709 about a GLP1 monotherapy of matched structure and pharmacokinetics disappeared in CNS Gipr knockout mice185. The main systems and target areas for GIP harmony with GLP1 stay to be determined, and especially there are clashing preclinical results that promote GIPR antagonism as a restorative choice for treating obesity184. FGF21 is produced largely from the liver under conditions of fasting, and lowers body weight by raising power expense via main and outer mechanisms310,311,312,313. It binds to the CCK1 receptor (CCK1R) to reduce food consumption via a decrease in dish size314,315,316. The CCK1R is extensively expressed in vagal afferents, the NTS and the AP317,318, suggesting that CCK sends the satiation signal using the vagus to the brainstem, from which the satiety signal is predicted to the hypothalamus.
These signs and symptoms can vary in seriousness and might affect an individual’s lifestyle during the treatment duration. Tesofensine’s impact on serotonin degrees might add to hunger suppression and boosted state of mind. Boosted serotonin availability can assist regulate satiety, reduce cravings, and promote a feeling of well-being. Tesofensine also has a subtle impact on your state of mind, making you really feel much more favorable, upbeat, and motivated.
From a bottom-view video recording, the animals‘ placement at x and y collaborates of rats‘ noses, forelimbs, hind-limbs, and tail base was tracked utilizing DeepLabCut software application (DLC) [34] A video was videotaped at 60 structures per 2nd (fps) with a resolution of 1280 x 720 pixels using a Kayeton camera (design KYT-U400-MCS2812R01). The forward locomotion was tracked utilizing the rats‘ facility mass of the hind-limbs approach and plotted as complete distance took a trip (centimeters) for 240 mins. 5-HTP/CB dosage versus tesofensine dosage plots were constructed and an oblique line (isobole) was drawn by signing up with the ED30 worths of the private parts. The theoretical ED30 value of the combination representing a pure additive interaction is located on this line [29, 30]
As orlistat prevents the lipid-soluble vitamins from being taken in, vitamin A, D, E, and K supplements should be thought about for long-lasting usage. With the information coming from the research study and trial sector, Tesofensine is emerging as the newest advancement therapy for reliable weight management. The performance has actually been examined somewhat in professional tests, which we’ll discuss in a succeeding section. This dual activity not only impacts appetite however also boosts metabolic process, adding to the peptide’s possible performance in weight management. We are dedicated to helping our customers reach their objectives with an effective and healthy and balanced method.