6.11.2022 dávali v televízii starý slovenský film Zemianska česť, na ktorý sme takmer zabudli. Nevieme, či ho v telke dávali v súvislosti s práve ubehnuvšími voľbami alebo hroziacimi predčasnými voľbami do parlamentu, ale či už tak alebo onak, načasovanie nemohlo byť lepšie. Ide totiž o satiru na predvolebnú frašku sfilmovanú podľa románu Jána Kalinčiaka Reštavrácia.

Napriek tomu, že román pochádza z roku 1860, je až neuveriteľné, ako nadčasovo je napísaný, pretože charaktery a charakteristiky postavičiek, ako aj ich správanie, možno napasovať na všetky politické figúrky, ktoré sme u nás doposiaľ mali a stále máme. No a rovnako aj na voličov, ktorí tieto politické figúrky volia.

Repríza televíznej klasiky nás priviedla k zamysleniu, kde sú korene takého správania a takých charakterov. Vzhľadom na dobu, kedy román vznikol, je zrejmé, že s tým určite nemá nič spoločné obdobie socializmu, na ktoré sa často zvaľuje všetko zlé, čo sa u nás dialo a deje. Takto sme sa správali už dávnom pred socializmom. Je to teda v nás, v národe, v našich génoch, že sme takým falošným, úplatným, bezzásadovým a bezcharakterným národom? Necháme sa kúpiť za klobásu či poldeci pálenky?

Odkaz románu do dnešnej doby

Dá sa teda pobaviť a zasmiať aj na takom starom filme? Určite áno, najmä keď si v jeho hrdinoch predstavíme naše súčasné politické postavičky. Realita dnešných dní však, bohužiaľ, nie je ani trochu zábavná, takže ide skôr o smiech cez slzy.

Ako sa to vo filme vlastne skončilo? Všetci sa pobratali, funkcie si podelili a obidve bandy vládli v podstate spolu. Nikoho ani vtedy nezaujímalo, ako je na tom krajina, ako sa vodí obyčajnému ľudu. Za všetko hovoria posledné slová filmu: „Nuž, ľa! Čo sa statočný zeman natrápi, kým vyjde na psí tridsiatok!“. A čo tak parafráza na súčasnú dobu: „Nuž, ľa! Čo sa statočná Slovač natrápi, kým vyjde na psí tridsiatok!“.

Nuž, od toho asi už nemáme ďaleko, keďže sa od Kalinčiakových čias vlastne nič nezmenilo. Ale môže sa, stačí iba odstaviť podarených politikov a hlavne volebný systém, ktorý im šafárenie umožňuje. Práve preto je tu tento portál, aby poukázal, kde je podstata tohto zla. Kým si neuvedomíme tieto fundamentálne okolnosti, nie je možné ani hľadať riešenia.

Román Reštavrácia a film Zemianska česť tak ostávajú nielen skvelou komédiou, ale aj mementom, že tváre sa síce menia, no politické taktiky ostávajú zhruba rovnaké. Voľby boli, sú a vždy budú iba fraškou pre verejnosť, zorganizovanou ziskuchtivými a mocibažnými indivíduami.

By Obecné 83 341 komentárov na Zemianska česť

83 341 Replies to “Zemianska česť”

  1. Modification in weight was -12.8%, -14.7%, and -3.2% with tirzepatide 10 mg, 15 mg, and sugar pill, specifically. Participants who attained ≥ 5% weight loss were 79%, 83%, and 32%, specifically. A1c was equally decreased by 2.1% with both tirzepatide 10 mg and 15 mg vs 0.5% with placebo. A post hoc evaluation showed that the proportion of individuals who boosted anti-diabetic therapy strength decreased in the tirzepatide arms and increased in the placebo arm. One of the most usual side effects in phase 3 RCTs of semaglutide 2.4 mg were nausea or vomiting, looseness of the bowels, vomiting and irregularity.

    Medications
    Electrophysiological recordings additionally discovered that NPE stimulated a strong inflection on NAcSh’s single-unit and populace activity that correlated with the start of the active awake brain state, a sign of sleep problems. Given that the significant adverse occasions leading to discontinuation in theproof-of-concept test were queasiness and throwing up attributable to naltrexone, a24-week phase II trial evaluated three doses of naltrexone with bupropion tofind one of the most bearable dosage with sufficient efficiency. The trial randomized 419obese based on bupropion alone 400 mg/d, 3 mix dosages ofnaltrexone/bupropion (NB) with naltrexone at 16 mg/d, 32 mg/d, or 48 mg andbupropion 400 mg/d, or sugar pill [38] Theplacebo deducted weight-loss was biggest (4.65% of body weight) in the NB 32mg/d team by last observation continued (LOCF) analysis because of higherdrop outs in the NB 48 mg/d team from nausea and throwing up [38]

    2001)although the full information of its medicinal profile are not extensively offered. Tesofensine peptide works by reducing appetite while at the same time enhancing resting energy expense and fat oxidation. It also modulates the activity of dopamine which affects a specific area of the brain to replicate the pleasure sensation of consuming food. To answer the inquiry of whether it is risk-free to shed 15 extra pounds in 4 weeks, the response is no. 1-2 extra pounds in a week is the recommended weight loss rate by wellness experts all over the world. So in 4 weeks

    As displayed in Fig 10 the sucrose consumption degrees practically returned to baseline after the shot of 5-HTP (Fig 10A) or tesofensine (Fig 10B) on the following day (day 8). This suggests that taste hostility is not likely to be the key system behind the anorexigenic impact of these appetite suppressants. To analyze sucrose’s perception, rats were educated to see a main port and offer between 2 and 5 licks in an empty sipper to get a 10 μL decrease consisting of either water or one of five sucrose remedies with differing focus (0.5, 1.3, 3.2, 7.9, or 20% w/v).
    B Boosts Cognitive Health And Wellness

    Moreover, heart price can be increased when liraglutide is used and, if this symptom lingers, the medicine might need to be stopped. The safety and security of liraglutide has actually not been shown among those that are older than 75 years; hence, it is not advised in this population [59] The adverse effects experienced by more than 20% of individuals that make use of orlistat for 2 years include fecal incontinence, oily identifying, and fatty feces. In one research study, the treatment discontinuation rate was 8.8% in the therapy team and 5.0% in the placebo team [19,20] Moreover, when people with obesity that try to lose weight instantly decrease their food intake, some experience severe constipation owing to decreased dietary fiber intake. Irregularity can be treated by orlistat, in addition to dietary fiber supplementation, by means of its stomach adverse effects.

    They work by inhibiting the isoform I of the monoamine oxidase enzyme, so that the blockade of the NE breakdown allows the boost of its concentration, together with that of 5-HT and DA. They have been generally suggested to treat MDD flowing with atypical signs and symptoms and stress and anxiety. The head weaving stereotypy was determined making use of the information obtained from DLC tracking of the angular variation of the Euclidean position of the nose concerning its base tail. Bits were made from the angular variant data by balancing 3600 data points corresponding to one minute of the session time.
    Given that the half-life of tesofensine is about 8 days, we proceeded evaluating the rats‘ performance for 3 even more days (S3 Fig, panel C). We observed no significant modification in job efficiency, or the palatability responses sucrose evoked during this duration. Our information recommend that tesofensine in rats did not harm sweetness detection or affect its palatability. One potential reason for the appetite-suppressing result of tesofensine (or 5-HTP) is that it may induce preference aversion. As displayed in Fig 10 the sucrose usage degrees practically went back to standard after the injection of 5-HTP (Fig 10A) or tesofensine (Fig 10B) on the next day (day 8).
    Bariatric surgical treatment may produce continual fat burning in some patients (14, 15) but is not an option for most because lasting safety and malabsorption issues might provide an obstacle (16, 17). In analogous trials of other anti-obesity medicines, net weight losses of 2.9 kg, 4.2 kg and 4.7 kg have been attained with orlistat, sibutramine and rimonabant, respectively, over the exact same time period. So, the authors suggest that tesofensine 0.5 mg daily for 6 months has the potential to induce weight management twice that caused by currently approved drugs, and Phase III tests are expected to start following year. At week 32, the AHI was substantially lower, with weight reduction, in the liraglutide team than in the placebo (− 12.2 ± 1.8 occasions h − 1 vs. − 6.1 ± 2.0 events h − 1) [44] Amongst the individuals that completed 4 years of therapy, the portion of individuals that achieved a minimum of 5% weight-loss was considerably higher in the orlistat group (52.8%) than in the sugar pill team (37.3%). At the end of the 4-year study, the collective incidence of diabetes mellitus was 9.0% in the placebo group and 6.2% in the orlistat team, with a risk decrease price of 37.3% [17]

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  20. Another challenge in weight-loss pharmacology is that persistent altitude of adiposity signals such as leptin and insulin lead to desensitization, causing a damaged responsiveness of this homeostatic system115,116,117.

    Relative Performance And Safety Of Pharmacological Techniques To The Management Of Excessive Weight
    Throughout saline shot days (left panel), neither GABAergic nor non-GABAergic neurons were modulated after saline injection. During optotagging (see 30– 66 mins), just GABAergic neurons (blue trace) reacted during laser stimulation. Effectiveness researches battle with the concern of how much added weight reduction is a good idea in a finite period, and the duration required for documenting it with confidence. Offered the efficiency that is being accomplished and the chronic nature of excessive weight, it is arguable that maintaining the rate in weight loss for subjects of ongoing excess weight is the key purpose. Shortening the research studies with the objective of increasing the loved one price of weight decrease may not verify recommended for the client and might cause damaging results that remove approaches that otherwise would confirm feasible, if used less strongly.
    Several tests evaluating using GLP-1 agonists as antiobesity drugs have been in development. A small study conducted in obese nondiabetic ladies with polycystic ovary disorder showed that a mix of exenatide with metformin positively influenced body weight, insulin sensitivity, and menstrual cyclicity. These advantageous impacts were a lot more noticable with mix treatment than with management either of exenatide or metformin alone (60 ). The Stage III trials will include 4 placebo-controlled research studies and will certainly sign up between 5,000 to 7,000 patients including those having type 2 diabetes mellitus and high blood pressure. Two of the 4 trials will certainly be performed for the excessive weight studies each for a period of one year. The tests will additionally include a two-year research study to observe the security and effectiveness of the drug on the cardiovascular system.

    Although most of these hypothalamic peptides have actually been suggested as targets for the advancement of unique anti-obesity medications, presently, there are very couple of prospects in medical growth and some very favoured approaches have actually fallen short to live up to expectations.

    New research study is disclosing the shocking mind and mental wellness advantages of semaglutide medicines such as Ozempic and Wegovy, and various other associated diabetic issues and weight-loss drugs that mimic a digestive tract hormone launched after eating.

    Cns Anti-obesity Medication Targets Because The Discovery Of Leptin
    We observed that rats treated with tesofensine 2 mg/kg showed different behavior compared to the control group. On the other hand, rats treated with tesofensine 6 mg/kg and phentermine, which both exhibited extra stereotypy, were organized in a tiny area but far away from the rats in the control and tesofensine 2 mg/kg groups (Fig 7E). Refresher courses are needed to explore the impacts of tesofensine on minimizing the probability of grooming actions and other tongue kinematics specifications. After showing the anorexigenic results of tesofensine in lean Vgat-ChR2 computer mice, we intended to reproduce our findings in obese Vgat-IRES-cre computer mice. We shared ChR2 in the LH via viral infection and subjected the computer mice to a high-fat diet or typical chow for 12 weeks (Fig 5A).
    2 Anti-obesity Medicines In Scientific Growth
    These results recommend that tesofensine generates weightloss mainly by decreasing food intake with a tiny rise in metabolicrate [121], A phase 2 test focusedon long term effects on hunger feelings in subjects given 0.25, 0.5 or 1 mgtesofensine or placebo for 24 weeks. There was a dose-dependent suppression ofhunger over the first 12 weeks which correlated with the amount of weight lostover the training course of the entire 6 month research, despite the fact that the effect on satietyfaded as weight-loss continued to proceed [122] In a rat version of diet-induced weight problems (DIO), tesofensine treatmentproduced robust weight management come with by hypophagia. To determine the neuralpathways regulating weight management and hypophagia, turnaround of these effects wasinvestigated making use of various monoaminergic receptor antagonists co-administeredwith tesofensine. Tesofensine considerably decreased food intake in the first 12hours of management in a dosage dependent manner, with an optimal impact after3 days. The hypophagic effect slowly dissipated and went back to manage levelsby day 15, yet the decrease in body weight proceeded for the duration of the 16day experiment.

    Zepbound & #x 2122; (ZEHP-bownd) is an injectable prescription medicine that might help adults with weight problems, or with excess weight (obese) who additionally have weight-related medical troubles, reduce weight and keep it off. It needs to be used with a reduced-calorie diet regimen and boosted exercise.

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  25. The combined results of consuming much less and melting more calories causes substantial weight reduction. Extra people in the pooled tesofensine therapy groups (81.5%) than in the placebo team (73.5%) seasoned negative occasions (Table 4). Individuals in the tesofensine therapy groups experienced a higher price of nervous system disorders (dyskinesia and headache), intestinal tract problems (queasiness and irregularity), and psychological problems (hallucinations and sleep problems). The occurrences of severe adverse events were 20.4% in the placebo group and 16.6% in the pooled tesofensine treatment teams.
    Twenty-four-week adjustment in outcomes in the customized intention-to-treat population of a randomized professional test of Tesomet for hypopituitary individuals with hypothalamic weight problems. Data presented as the very least squares mean (95% CI) change from standard to week 24 in the glove populace. Pair-wise contrasts were executed utilizing a baseline adjusted ANCOVA design with therapy as element and modification from baseline as reliant variable.

    But the firm’s new Threat Assessment and Reduction Method (REMS) framework promises to make it possible for drugmakers to begin collaborating with nationwide health authorities to develop approaches to report and manage danger as they look for NDAs.

    Hypothalamic weight problems is a tough problem to deal with, as there are presently no authorized or effective pharmacological treatments. Nonetheless, tesofensine is a novel substance with potential in human researches and might be an encouraging choice for these clients [38] The 2nd larger team of cells that were a lot more strongly regulated by tesofensine in obese than in lean rats was the set of neurons displaying a robust inhibition (see E1 in Fig 2).
    However, the accuracy of the sucrose detection job (i.e., the percent proper trials) was not dramatically altered by tesofensine (S3 Fig). Having shown the neuronal correlates of tesofensine in the LH in rats and computer mice, we compared tesofensine hunger suppressant effects with various other cravings suppressants, especially phentermine and 5-HTP. The 5-HT6 receptor is a promising new CNS target for obesity177 and a variety of pharmaceutical companies are creating careful 5-HT6 receptor ligands as prospective anti-obesity agents. Interestingly, both discerning 5-HT6 receptor agonists and villains are being created for obesity by various firms (see below). As talked about carefully above, molecular targets for obesity are lots of and differed, varying from alterations of existing therapies, such as monoamine reuptake and lipase inhibitors, to unique natural chemical and neuropeptide receptors. Due to past failings and medicine withdrawals (see over) the pharmaceutical market faces an increasingly uphill job in convincing the regulatory authorities of the effectiveness and, specifically, the safety and security of new medications to treat weight problems.
    In this article, discover exactly how to feel sorry for your future self, exactly how to make individual treatment a concern. When it involves health and fitness, it’s finest to quit thinking (it melts no fat and develops no muscular tissue) and begin acting to see outcomes quickly. The longer you wait to make weight loss a priority, the harder you’re making the process on your future self when you do shoot.
    Furthermore, it will be relevant to recognize the difference either in the distribution or physical properties of the receptors indirectly targeted by tesofensine in overweight versus lean mice. These researches will clarify the neurochemical account of each appetite suppressant and will certainly guide us in identifying and integrating them much better. A human research study discovered that tesofensine enhanced satiation and lowered cravings for wonderful foods after 12 weeks of therapy [19] To explore this better, we used a psychophysical sucrose detection task in rats to identify whether tesofensine influences taste perception.
    As I discussed previously in this post, there are other peptide heaps for weight reduction you can experiment with (Tesamorelin + Ipamorelin OR Ipamorelin + CJC-1295 without DAC). So from my very own first-hand experience and those of my private coaching clients, the most effective peptide pile for fat loss goes to Tesofensine + Semaglutide and AOD9604. MOTS-C can likewise enhance insulin level of sensitivity, increase fat malfunction, improve your energy levels, and even enhance mitochondrial health. Semaglutide is one of the best peptides for reducing since it straight attends to the unfavorable actions of over-eating and kills your hunger.

    So this is not something which is about reports, many research studies have revealed real weight loss assurance in people, not just animal and in vitro research studies. As a powerful triple-reuptake inhibitor, it ensures the body can preserve raised degrees of the three essential neurochemicals for weight management, dopamine, serotonin, and norepinephrine. That exact same study revealed a maximal weight management capacity of 10.6% in individuals that were overweight, which is about twice the rate of weight management that can be seen in comparable anti-obesity representatives.
    As a result, the development of pharmacotherapies to attend to the pathology underlying the dysregulation of power homeostasis is essential. Tesofensine Peptide works by preventing the upgrade of the neurotransmitters dopamine, serotonin, and noradrenaline. The body reacts by decreasing cravings and cravings, making individuals much more inclined to have smaller sized meals and much less most likely to snack. One more research study discovered that tesofensine can enhance power by boosting dopamine and norepinephrine degrees, which regulate inspiration, power, rate of interest, and drive. As a result of its modulating result on dopamine (additionally called the „delighted hormonal agent“) in a specific section of the brain, tesofensine appears to influence food consumption-induced pleasure. 5-HTP/CB dose versus tesofensine dose stories were built and an oblique line (isobole) was drawn by signing up with the ED30 worths of the specific components.

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